Polynucleotides

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Polynucleotides are an innovative injectable treatment designed to naturally rejuvenate the skin. They are made from purified fragments of fish DNA, and work to improve skin quality from within. 

Polynucleotides act at a cellular level, stimulating fibroblast activity which boosts collagen and elastin production. They promote cell renewal and improve blood flow, resulting in firmer, smoother, and more radiant skin. 

Polynucleotides also calm inflammation and rebalance melanocyte activity to promote a more even skin tone. Unlike dermal fillers, polynucleotides add no volume. 

Certain formulations include hyaluronic acid for additional hydration, your Revitalise doctor will advise which option best suits your needs.

Polynucleotides are highly versatile, suitable for use all over the body. Popular treatment areas include the under‑eye area (ideal for dark circles and fine lines) as well as the face, neck, décolletage, hands, and scalp for hair improvement. 

Their gentle yet powerful action makes them perfect for delicate zones that are difficult to treat with other injectables, and they can also be used to improve the appearance of scars and stretch marks.

Polynucleotides are injected just beneath the skin’s surface with a very fine needle or a blunt-ended cannula.  We recommend applying local anaesthetic cream to the area 30 minutes before your treatment. 

For optimal results, we recommend a course of three Polynucleotide treatments, spaced 2–4 weeks apart. Follow‑up maintenance sessions every 6 months will help keep your skin looking its best. Most people see the first signs of improvement after about four weeks as natural skin regeneration begins, with further visible benefits developing over the next 6–12 weeks.

Our Revitalise Medical doctors will explain exactly what to expect from your polynucleotide treatment. Depending on the injection technique and treatment area, you may notice swelling or a bumpy appearance of the skin. Occasionally, redness, tenderness, itching, or mild bruising can occur. These temporary side effects usually disappear within a few days; if they persist or if you experience any other reactions, please contact us.

Post‑treatment aftercare for polynucleotide injections

• Avoid touching the treated area for at least six hours to minimise infection risk.
• Avoid make‑up for 24 hours.
• Until initial swelling or redness resolves, keep the area away from intense heat (sunbathing, saunas) and extreme cold.
• Refrain from alcohol for 24 hours before and after your session, and avoid strenuous exercise or swimming during the same period.
• You may apply a broad‑spectrum sunscreen to protect the newly treated skin.